genomic region – Communicable Diseases Research

Insertion/deletion hotspots in the Nsp2, Nsp3, S1, and ORF8 genes of SARS-related coronaviruses

Article

Published on 2022-10-282022-11-16
Journal: BMC Ecology and Evolution
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome animal hosts base bases bat bat coronavirus benefit Characteristics classical complex coronavirus determine Frame Future Genome genomic region hotspot Human human SARS-CoV-2 human SARS-CoV-2 strain INDEL Indel hotspot indels insertion/deletion insertion/deletion (indel). mechanism Multiple sequence alignment Mutation N-terminal domain Neutral non-structural protein Occurrence offer ORF8 ORF8 gene pangolin Pangolin coronavirus (PCoV) Point mutation RaTG13 Region reported RNA sequence S1 domain SARS-CoV SARS-CoV-2 SARS-related coronavirus SARS-related coronaviruses severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) survival the spike protein viral evolution virus virus viruses
[DOI] 10.1186/s12862-022-02078-7 PMC 바로가기

SARS-CoV-2 wastewater monitoring using a novel PCR-based method rapidly captured the Delta-to-Omicron ΒΑ.1 transition patterns in the absence of conventional surveillance evidence

Article

Published on 2022-10-202022-11-15
Journal: The Science of the total environment
[Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제,

[키워드] absence acquisition amplify Analysis applicability approach characterized clinical sample Conventional Delta delta variant Delta wave dependent on described doubling early warning epidemic wave epidemiological situation Epidemiology Evidence genomic genomic region genotyping Greece influence information Measures methodology omicron Omicron BA.1 PCR amplification PCR-based method plant Prevalence proportion provide Public health interventions quantification rapid increase reached real-time RT-PCR reported SARS-CoV-2 SARS-CoV-2 surveillance selective Sequencing state Surveillance surveillance data Thessaloniki variant Viral load virus wastewater Wastewater-based epidemiology.
[DOI] 10.1016/j.scitotenv.2022.156932 PMC 바로가기

Detection of the Omicron variant of SARS-CoV-2 in international travelers returning to Venezuela

베네수엘라로 귀국하는 해외 여행자에서 SARS-CoV-2의 오미크론 변종 검출

Article

Published on 2022-07-012022-09-11
Journal: Travel medicine and infectious disease
[Category] COVID19(2023년), SARS, 변종, 치료기술,

Proof of concept for multiplex amplicon sequencing for mutation identification using the MinION nanopore sequencer

Research

Published on 2022-05-202022-10-05
Journal: Scientific Reports
[Category] 변종,

Development and Validation of Two RT-qPCR Diagnostic Assays for Detecting Severe Acute Respiratory Syndrome Coronavirus 2 Genomic Targets across Two Specimen Types

두 가지 표본 유형에 걸친 중증 급성 호흡기 증후군 코로나바이러스 2 게놈 표적 검출을 위한 두 가지 RT-qPCR 진단 어세이의 개발 및 검증

Article

Published on 2022-04-012022-09-11
Journal: The Journal of molecular diagnostics : JMD
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition authorization CDC clinical evaluation Clinicians Community coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Department described development diagnostic Emergency Factors foundation Genetic variation genomic region Health Organization Laboratory limit of detection Lower nasopharyngeal New York outbreak pandemic Patient care patients reagents respiratory respond RT-qPCR RT-qPCR assays Saliva SARS-CoV-2 severe acute respiratory syndrome Coronavirus specimen state subsequent Supply chain supply shortage target Type validation variant Viral detection World Health Organization
[DOI] 10.1016/j.jmoldx.2021.12.010 PMC 바로가기 [Article Type] Article

Improved Binding Affinity of Omicron’s Spike Protein for the Human Angiotensin-Converting Enzyme 2 Receptor Is the Key behind Its Increased Virulence

인간 안지오텐신 전환 효소 2 수용체에 대한 오미크론 스파이크 단백질의 향상된 결합 친화도는 독성 증가의 핵심입니다

Article

Published on 2022-03-212022-09-11
Journal: International Journal of Molecular Sciences
[Category] SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affinity Amino acid amino acid residue amino acids angiotensin Antiviral agents binding binding free energies binding free energy characterized complex contribute coronavirus country D38 domain electrostatic interaction enzyme exhibited free energy genomic region hACE2 hACE2 receptor Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human angiotensin-converting enzyme 2 (hACE2) hydrogen hydrogen bonding Improved Increased information Interaction investigated mode molecular molecular dynamics Molecular dynamics simulation Molecular mechanics molecular mechanics-generalized Born surface area (MM-GBSA) mutated Mutation omicron Omicron variant Other pi-stacking RBD receptor Receptor-binding domain Receptor-binding domain (RBD) receptor-binding motif Receptor-binding motif (RBM) residue resulting salt bridges SARS-CoV-2 SARS-CoV-2 RBD Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). spike Spike protein surface area the RBD the spike protein Transmissibility tyrosine variant variant of SARS-CoV-2 virus wild type
[DOI] 10.3390/ijms23063409 PMC 바로가기 [Article Type] Article

Evaluation of Spike Protein Epitopes by Assessing the Dynamics of Humoral Immune Responses in Moderate COVID-19

중간 정도의 COVID-19에서 체액 면역 반응의 역학을 평가하여 스파이크 단백질 에피토프 평가

Article

Published on 2022-03-182022-09-12
Journal: Frontiers in Immunology
[Category] MERS, SARS, 진단,

[키워드] AbMap acute respiratory syndrome analyses Analysis antibody binding epitope Antigen Assessing caused change Characteristics Cohort comparable Comprehensive conserved coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients demonstrated Diagnosis distribution domains Dynamics ELISA enzyme-linked immunosorbent epitope genomic region homotrimer Hospitalization Hospitalized host immunity humoral humoral immune response IgG IgG antibody IgM immune immune system Immunotherapy in viral Infection information Microarray microarray. Moderate COVID-19 Novel coronavirus pandemic Patient peptide peptide microarray peptides provided random reactivity recombinant response S protein S protein epitope S proteins S1 protein SARS-CoV-2 serum sample Seven spike spike gene sequence Spike protein suggested symptom onset the S protein Vaccine development were used
[DOI] 10.3389/fimmu.2022.770982 PMC 바로가기 [Article Type] Article

Unsupervised explainable AI for molecular evolutionary study of forty thousand SARS-CoV-2 genomes

Research

Published on 2022-03-102022-10-28
Journal: BMC Microbiology
[Category] COVID-19, MERS, SARS,

Genomic Bootstrap Barcodes and Their Application to Study the Evolution of Sarbecoviruses

Article

Published on 2022-02-212022-10-28
Journal: Viruses
[Category] COVID-19, COVID19(2023년), SARS,

Population genomics and geographic dispersal in Chagas disease vectors: Landscape drivers and evidence of possible adaptation to the domestic setting

차가스 질병 벡터의 인구 유전체학 및 지리적 분산 : 국내 환경에 대한 조경 동인 및 가능한 적응의 증거

Research Article

Published on 2022-02-042022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,